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Improving the fit

Ideas for complementary experiments

• The vesicles could be imaged, e.g. with electron microscopy, to get an independent estimation of its structure, number of layers, polydispersity etc.
• Chemical assays could be used to determine the lipid content.
• The overall vesicle size may be determined with dynamic light scattering.

Ideas for improving the model

• The model contains no information about the shape of the vesicle, but instead assumes that the vesicles are infinitely large (radius->inf) - maybe a finite vesicle radius could be built into the model?
• Use Gassian smearing of edges/interfaces instead of uniform SLD profiles (Li et al, 2023).
• There may be polydispersity (not all particles are the same) in the multilamellar model (lamellar_hg_stack_caille), e.g., the vesicles may contain different number of layers (polydispersity in the parameter Nlayers)